Seed Funding Program 2023
UCGLORI
Epitranscriptomics of urothelial carcinoma
Coordinators
Malin Nientiedt
Urology, UMM
Frank Lyko
Epigenetics, DKFZ
Detailed description
Urothelial carcinoma of the bladder (UCB) is the 10th most common cancer worldwide and causes significant morbidity and mortality in our healthcare systems. A deeper understanding of tumor biology is essential to improve current diagnostics and therapy. This project will provide the first characterization of the UCB-specific epitranscriptome, the distribution pattern of the most important RNA modification, at single-base resolution and thus provide fundamentally important information to understand the role of this mRNA modification in carcinogenesis. In addition, our results will also provide a critical resource to develop novel epitranscriptomic biomarkers for patient stratification.
